2-Chloro-5-nitronicotinic acid
2-Chloro-5-nitronicotinic acid
CAS: 42959-38-6
Molecular Formula: C6H3ClN2O4
2-Chloro-5-nitronicotinic acid - Names and Identifiers
2-Chloro-5-nitronicotinic acid - Physico-chemical Properties
| Molecular Formula | C6H3ClN2O4 |
| Molar Mass | 202.55 |
| Density | 1.702±0.06 g/cm3(Predicted) |
| Melting Point | 140-143℃ |
| Boling Point | 384.8±42.0 °C(Predicted) |
| Flash Point | 186.5°C |
| Vapor Presure | 1.31E-06mmHg at 25°C |
| Appearance | Solid |
| Color | White to yellow |
| pKa | 1.57±0.10(Predicted) |
| Storage Condition | 2-8℃ |
| Sensitive | Moisture Sensitive |
| Refractive Index | 1.637 |
2-Chloro-5-nitronicotinic acid - Risk and Safety
| Risk Codes | 22 - Harmful if swallowed |
| Hazard Class | IRRITANT |
2-Chloro-5-nitronicotinic acid - Reference Information
| Properties | 2-chloro-5-nitronicotinic acid, its molecular formula is C6H3ClN2O4, molecular weight is 202.55,CAS number is 42959-38-6, melting point 140-143°C, white or yellow solid. |
| Application | 2-chloro-5-nitronicotinic acid is a chemical intermediate used in the synthesis of pesticides and medicines. For example, French Rhone-Planck Agricultural Co., Ltd. uses it to synthesize new herbicides. |
| Synthesis method | France Rhone-Planck Agricultural Co., Ltd. proposed a two-step preparation of 2-chloro-5-nitronicotinic acid from 2-hydroxynicotinic acid The solution: 1) Add fuming nitric acid (26ml) to a concentrated H2SO4(100ml) solution of stirred 2-hydroxynicotinic acid (34.8g) at 35-40°C. The resulting mixture was stirred at 50°C for 4 hours. Cool the mixture to room temperature and pour on ice. The precipitate was filtered and collected, air-dried on a filter, and recrystallized from ethanol to obtain 2-hydroxy-5-nitronicotinic acid, which is a light yellow solid (39.6g);2) Dimethylformamide (4 drops) was added to 2-hydroxy-5-nitronicotinic acid (5g) in phosphoryl chloride (10ml). The mixture was stirred at reflux temperature for 3 hours. The excess solvent is evaporated and removed, and the residue is carefully poured into the water to maintain the temperature below 40 ℃. The mixture was stirred for a further 30 minutes at room temperature and then extracted with ethyl acetate. The extract was washed with water, dried (MgSO4), and evaporated to dry. The obtained residue was co-researched with ether/hexane to obtain 2-chloro-5-nitronicotinic acid, which was a light yellow oil (3.6g). |
Last Update：2024-04-09 21:01:54
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View History
2-Chloro-5-nitronicotinic acid
68480-07-9
Gadobutrol Impurity 144
4781-82-2
华法林
Protex NX 3
Red E-BM
1092-04-2
6574-83-0
NEOCHLOROGENIC ACID 新绿原酸
68480-07-9
Gadobutrol Impurity 144
4781-82-2
华法林
Protex NX 3
Red E-BM
1092-04-2
6574-83-0
NEOCHLOROGENIC ACID 新绿原酸